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ppandora rings The red flag with the highest post test probability for detection of spinal malignancy was history of malignancy (33%, 22% to 46%).Conclusions While several red flags are endorsed in guidelines to screen for fracture or malignancy, only a small subset of these have evidence that they are indeed informative. These findings suggest a need for revision of many current guidelines.IntroductionLow back pain is a major cause of disability,1 leading to considerable healthcare expenditure around the world, especially in high income countries.2 The difficulty in providing a definitive diagnosis for most presentations of back pain has given rise to the term “non specific low back pain,” which is generally considered to be benign and can be managed in a primary care setting.3 Some patients, however, present with low back pain as the initial manifestation of a more serious pathology, such as malignancy, spinal fracture, infection, or cauda equina syndrome. Spinal fracture and malignancy are the most common serious pathologies affecting the spine. pandora rings
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